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Nr3c1 Gene Detail
Summary
  • Symbol
    Nr3c1
  • Name
    nuclear receptor subfamily 3, group C, member 1
  • Synonyms
    glucocorticoid receptor, GR, Grl-1, Grl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95824
    NCBI Gene: 14815
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:39543598-39652474 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 21.09 cM
  • Mapping Data
    30 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2582 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95824
 protein coding gene Chr18:39543598-39652485 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024368
 protein coding gene Chr18:37951432-38030897 (-)
A/J MGP_AJ_G0024335
 protein coding gene Chr18:36617754-36697539 (-)
AKR/J MGP_AKRJ_G0024304
 protein coding gene Chr18:37611248-37693144 (-)
BALB/cJ MGP_BALBcJ_G0024335
 protein coding gene Chr18:36678402-36759152 (-)
C3H/HeJ MGP_C3HHeJ_G0024101
 protein coding gene Chr18:37689405-37771747 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024777
 protein coding gene Chr18:39253316-39336766 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022216
 protein coding gene Chr18:36613924-36693266 (-)
CAST/EiJ MGP_CASTEiJ_G0023576
 protein coding gene Chr18:37653206-37735448 (-)
CBA/J MGP_CBAJ_G0024071
 protein coding gene Chr18:40446918-40537867 (-)
DBA/2J MGP_DBA2J_G0024201
 protein coding gene Chr18:36201685-36283673 (-)
FVB/NJ MGP_FVBNJ_G0024167
 protein coding gene Chr18:35932221-36011556 (-)
LP/J MGP_LPJ_G0024285
 protein coding gene Chr18:37985461-38069632 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024198
 protein coding gene Chr18:41625443-41716049 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024826
 protein coding gene Chr18:37498497-37582528 (-)
PWK/PhJ MGP_PWKPhJ_G0023320
 protein coding gene Chr18:36448704-36529695 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023125
 protein coding gene Chr18:37740156-37820115 (-)
WSB/EiJ MGP_WSBEiJ_G0023639
 protein coding gene Chr18:37384711-37470211 (-)



Homology
more
  • Human Ortholog
    NR3C1, nuclear receptor subfamily 3 group C member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR3C1, nuclear receptor subfamily 3 group C member 1
  • Synonyms
    GCCR, GCR, GCRST, GR, GRL
  • Links
    NCBI Gene ID: 2908
    neXtProt AC: NX_P04150
    UniProt: P04150

  • Chr Location
    5q31.3; chr5:143277931-143435512 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nr3c1 mouse models; 12 with human NR3C1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    141 phenotypes from 13 alleles in 23 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    293 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die at birth of respiratory failure with underdeveloped lungs, enlarged adrenals, elevated serum corticosterone and ACTH, and failed adrenaline synthesis. Mice with a point mutation have impaired gluconeogenesis and erythropoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    138
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1200
  • Tissues
    288
  • cDNA Data
    140
  • Literature Summary
    71
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024431 Ensembl Gene Model | MGI Sequence Detail 108877 C57BL/6J ±  kb
    transcript ENSMUST00000097592 Ensembl | MGI Sequence Detail 2382 Not Applicable  
    polypeptide ENSMUSP00000095199 Ensembl | MGI Sequence Detail 793 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 172
      Genomic 14
      cDNA 142
      Primer pair 14
      Other 2

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-10262, MGD-MRK-10263
    References
    more
    • Summaries
      All 537
      Developmental Gene Expression 71
      Diseases 1
      Gene Ontology 35
      Phenotypes 293
    • Earliest
      J:6459 Francke U, et al., Chromosome assignment of a murine glucocorticoid receptor gene (Grl-1) using intraspecies somatic cell hybrids. Cell. 1980 Dec;22(3):657-64
    • Latest
      J:359223 Zhou L, et al., Glucocorticoids induce a maladaptive epithelial stress response to aggravate acute kidney injury. Sci Transl Med. 2024 Oct 2;16(767):eadk5005
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory